ParkinsonCanadaV1, Main, Exploration, bibRecord, 003063

PARK3 influences age at onset in parkinson disease: A genome scan in the GenePD study

Identifieur interne : 003063 ( Main/Exploration ); précédent : 003062; suivant : 003064

PARK3 influences age at onset in parkinson disease: A genome scan in the GenePD study

Auteurs : Anita L. Destefano [États-Unis] ; Mark F. Lew [États-Unis] ; Lawrence I. Golbe [États-Unis] ; Margery H. Mark [États-Unis] ; Alice M. Lazzarini [États-Unis] ; Mark Guttman [Canada] ; Erwin Montgomery [États-Unis] ; Cheryl H. Waters [États-Unis] ; Carlos Singer [États-Unis] ; Ray L. Watts [États-Unis] ; Lillian J. Currie [États-Unis] ; G. Frederick Wooten [États-Unis] ; Nancy E. Maher [États-Unis] ; Jemma B. Wilk [États-Unis] ; Kristin M. Sullivan [États-Unis] ; Karen M. Slater [États-Unis] ; Marie H. Saint-Hilaire [États-Unis] ; Robert G. Feldman [États-Unis] ; Oksana Suchowersky [Canada] ; Anne-Louise Lafontaine [Canada] ; Nancy Labelle [Canada] ; John H. Growdon [États-Unis] ; Peter Vieregge [Allemagne] ; Peter P. Pramstaller [Italie] ; Christine Klein [Allemagne] ; Jean P. Hubble [États-Unis] ; Carson R. Reider [États-Unis] ; Mark Stacy [États-Unis] ; Marcy E. Macdonald [États-Unis] ; James F. Gusella [États-Unis] ; Richard H. Myers [États-Unis]

Source :

American journal of human genetics [ 0002-9297 ] ; 2002.

RBID : Pascal:02-0419048

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Caractère autosomique, Caractère récessif, Parkinsonisme, Précoce, Précocité, Variabilité, Age apparition, Idiopathique, Liaison génétique, Composante variance, Méthodologie, Génome, Tardif, Gène, Chromosome A2, Responsabilité, Population, Fratrie, Maximum, Chromosome A1.
Wicri :
- topic : Responsabilité.

English descriptors

KwdEn :
- Age of onset, Autosomal character, Chromosome A1, Chromosome A2, Earliness, Early, Gene, Genome, Idiopathic, Late, Linkage, Maximum, Methodology, Parkinson disease, Parkinsonism, Population, Recessive character, Responsibility, Sibling, Variability, Variance component.

Abstract

Parkinson disease (PD) is a late-onset neurodegenerative disorder. The mean age at onset is 61 years, but the disease can range from juvenile cases to cases in the 8th or 9th decade of life. The parkin gene on chromosome 6q and loci on chromosome 1p35-36 and 1p36 are responsible for some cases of autosomal recessive early-onset parkinsonism, but they do not appear to influence susceptibility or variability of age at onset for idiopathic PD. We have performed a genomewide linkage analysis using variance-component methodology to identify genes influencing age at onset of PD in a population of affected relatives (mainly affected sibling pairs) participating in the GenePD study. Four chromosomal loci showed suggestive evidence of linkage: chromosome 2p (maximum multipoint LOD [MaxLOD] = 2.08), chromosome 9q (MaxLOD = 2.00), chromosome 20 (MaxLOD = 1.82), and chromosome 21 (MaxLOD = 2.21). The 2p and 9q locations that we report here have previously been reported as loci influencing PD affection status. Association between PD age at onset and allele 174 of marker D2S1394, located on 2p13, was observed in the GenePD sample (P = .02).

Affiliations:

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Le document en format XML

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<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Neurology, Massachusetts General Hospital, Harvard Medical School</s1>
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<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Neurology, Massachusetts General Hospital, Harvard Medical School</s1>
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<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University Schools of Medicine and of Public Health</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">02-0419048</idno>
<date when="2002">2002</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">PARK3 influences age at onset in parkinson disease: A genome scan in the GenePD study</title>
<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University Schools of Medicine and of Public Health</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Biostatistics, Boston University Schools of Medicine and of Public Health</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F." last="Lew">Mark F. Lew</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Neurology, University of Southern California</s1>
<s2>Los Angeles</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I." last="Golbe">Lawrence I. Golbe</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, NJ</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>New Brunswick, NJ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, NJ</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>New Brunswick, NJ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lazzarini, Alice M" sort="Lazzarini, Alice M" uniqKey="Lazzarini A" first="Alice M." last="Lazzarini">Alice M. Lazzarini</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, NJ</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>New Brunswick, NJ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Medicine, University of Toronto</s1>
<s2>Toronto</s2>
<s3>CAN</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Montgomery, Erwin" sort="Montgomery, Erwin" uniqKey="Montgomery E" first="Erwin" last="Montgomery">Erwin Montgomery</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1>
<s2>Cleveland</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cleveland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Waters, Cheryl H" sort="Waters, Cheryl H" uniqKey="Waters C" first="Cheryl H." last="Waters">Cheryl H. Waters</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Neurology, University of Southern California</s1>
<s2>Los Angeles</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, University of Miami</s1>
<s2>Miami</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Miami</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Emory University School of Medicine</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Currie, Lillian J" sort="Currie, Lillian J" uniqKey="Currie L" first="Lillian J." last="Currie">Lillian J. Currie</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, University of Virginia Health System</s1>
<s2>Charlottesville, VA</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Charlottesville, VA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wooten, G Frederick" sort="Wooten, G Frederick" uniqKey="Wooten G" first="G. Frederick" last="Wooten">G. Frederick Wooten</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, University of Virginia Health System</s1>
<s2>Charlottesville, VA</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Charlottesville, VA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maher, Nancy E" sort="Maher, Nancy E" uniqKey="Maher N" first="Nancy E." last="Maher">Nancy E. Maher</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University Schools of Medicine and of Public Health</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wilk, Jemma B" sort="Wilk, Jemma B" uniqKey="Wilk J" first="Jemma B." last="Wilk">Jemma B. Wilk</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University Schools of Medicine and of Public Health</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
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<sZ>31 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sullivan, Kristin M" sort="Sullivan, Kristin M" uniqKey="Sullivan K" first="Kristin M." last="Sullivan">Kristin M. Sullivan</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University Schools of Medicine and of Public Health</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
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<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Slater, Karen M" sort="Slater, Karen M" uniqKey="Slater K" first="Karen M." last="Slater">Karen M. Slater</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University Schools of Medicine and of Public Health</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
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<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Saint Hilaire, Marie H" sort="Saint Hilaire, Marie H" uniqKey="Saint Hilaire M" first="Marie H." last="Saint-Hilaire">Marie H. Saint-Hilaire</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University Schools of Medicine and of Public Health</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feldman, Robert G" sort="Feldman, Robert G" uniqKey="Feldman R" first="Robert G." last="Feldman">Robert G. Feldman</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University Schools of Medicine and of Public Health</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1>
<s2>Calgary</s2>
<s3>CAN</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
<orgName type="university">Université de Calgary</orgName>
</affiliation>
</author>
<author><name sortKey="Lafontaine, Anne Louise" sort="Lafontaine, Anne Louise" uniqKey="Lafontaine A" first="Anne-Louise" last="Lafontaine">Anne-Louise Lafontaine</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1>
<s2>Calgary</s2>
<s3>CAN</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
<orgName type="university">Université de Calgary</orgName>
</affiliation>
</author>
<author><name sortKey="Labelle, Nancy" sort="Labelle, Nancy" uniqKey="Labelle N" first="Nancy" last="Labelle">Nancy Labelle</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1>
<s2>Calgary</s2>
<s3>CAN</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
<orgName type="university">Université de Calgary</orgName>
</affiliation>
</author>
<author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Neurology, Massachusetts General Hospital, Harvard Medical School</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vieregge, Peter" sort="Vieregge, Peter" uniqKey="Vieregge P" first="Peter" last="Vieregge">Peter Vieregge</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurology, Medical University of Lübeck</s1>
<s2>Lübeck</s2>
<s3>DEU</s3>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Medical University of Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, General Regional Hospital Bolzano</s1>
<s2>Bolzano</s2>
<s3>ITA</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bolzano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurology, Medical University of Lübeck</s1>
<s2>Lübeck</s2>
<s3>DEU</s3>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Medical University of Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hubble, Jean P" sort="Hubble, Jean P" uniqKey="Hubble J" first="Jean P." last="Hubble">Jean P. Hubble</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, Ohio State University</s1>
<s2>Columbus, OH</s2>
<s3>USA</s3>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Columbus, OH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reider, Carson R" sort="Reider, Carson R" uniqKey="Reider C" first="Carson R." last="Reider">Carson R. Reider</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, Ohio State University</s1>
<s2>Columbus, OH</s2>
<s3>USA</s3>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Columbus, OH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stacy, Mark" sort="Stacy, Mark" uniqKey="Stacy M" first="Mark" last="Stacy">Mark Stacy</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology, Barrow Clinic</s1>
<s2>Phoenix</s2>
<s3>USA</s3>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Phoenix</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Macdonald, Marcy E" sort="Macdonald, Marcy E" uniqKey="Macdonald M" first="Marcy E." last="Macdonald">Marcy E. Macdonald</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Neurology, Massachusetts General Hospital, Harvard Medical School</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gusella, James F" sort="Gusella, James F" uniqKey="Gusella J" first="James F." last="Gusella">James F. Gusella</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Neurology, Massachusetts General Hospital, Harvard Medical School</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University Schools of Medicine and of Public Health</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">American journal of human genetics</title>
<title level="j" type="abbreviated">Am. j. hum. genet.</title>
<idno type="ISSN">0002-9297</idno>
<imprint><date when="2002">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">American journal of human genetics</title>
<title level="j" type="abbreviated">Am. j. hum. genet.</title>
<idno type="ISSN">0002-9297</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of onset</term>
<term>Autosomal character</term>
<term>Chromosome A1</term>
<term>Chromosome A2</term>
<term>Earliness</term>
<term>Early</term>
<term>Gene</term>
<term>Genome</term>
<term>Idiopathic</term>
<term>Late</term>
<term>Linkage</term>
<term>Maximum</term>
<term>Methodology</term>
<term>Parkinson disease</term>
<term>Parkinsonism</term>
<term>Population</term>
<term>Recessive character</term>
<term>Responsibility</term>
<term>Sibling</term>
<term>Variability</term>
<term>Variance component</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Caractère autosomique</term>
<term>Caractère récessif</term>
<term>Parkinsonisme</term>
<term>Précoce</term>
<term>Précocité</term>
<term>Variabilité</term>
<term>Age apparition</term>
<term>Idiopathique</term>
<term>Liaison génétique</term>
<term>Composante variance</term>
<term>Méthodologie</term>
<term>Génome</term>
<term>Tardif</term>
<term>Gène</term>
<term>Chromosome A2</term>
<term>Responsabilité</term>
<term>Population</term>
<term>Fratrie</term>
<term>Maximum</term>
<term>Chromosome A1</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Responsabilité</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson disease (PD) is a late-onset neurodegenerative disorder. The mean age at onset is 61 years, but the disease can range from juvenile cases to cases in the 8th or 9th decade of life. The parkin gene on chromosome 6q and loci on chromosome 1p35-36 and 1p36 are responsible for some cases of autosomal recessive early-onset parkinsonism, but they do not appear to influence susceptibility or variability of age at onset for idiopathic PD. We have performed a genomewide linkage analysis using variance-component methodology to identify genes influencing age at onset of PD in a population of affected relatives (mainly affected sibling pairs) participating in the GenePD study. Four chromosomal loci showed suggestive evidence of linkage: chromosome 2p (maximum multipoint LOD [MaxLOD] = 2.08), chromosome 9q (MaxLOD = 2.00), chromosome 20 (MaxLOD = 1.82), and chromosome 21 (MaxLOD = 2.21). The 2p and 9q locations that we report here have previously been reported as loci influencing PD affection status. Association between PD age at onset and allele 174 of marker D2S1394, located on 2p13, was observed in the GenePD sample (P = .02).</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Canada</li>
<li>Italie</li>
<li>États-Unis</li>
</country>
<region><li>Alberta</li>
<li>Californie</li>
<li>Massachusetts</li>
<li>Ontario</li>
</region>
<settlement><li>Boston</li>
<li>Calgary</li>
<li>Los Angeles</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université de Calgary</li>
<li>Université de Californie du Sud</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
</region>
<name sortKey="Currie, Lillian J" sort="Currie, Lillian J" uniqKey="Currie L" first="Lillian J." last="Currie">Lillian J. Currie</name>
<name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<name sortKey="Feldman, Robert G" sort="Feldman, Robert G" uniqKey="Feldman R" first="Robert G." last="Feldman">Robert G. Feldman</name>
<name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I." last="Golbe">Lawrence I. Golbe</name>
<name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name>
<name sortKey="Gusella, James F" sort="Gusella, James F" uniqKey="Gusella J" first="James F." last="Gusella">James F. Gusella</name>
<name sortKey="Hubble, Jean P" sort="Hubble, Jean P" uniqKey="Hubble J" first="Jean P." last="Hubble">Jean P. Hubble</name>
<name sortKey="Lazzarini, Alice M" sort="Lazzarini, Alice M" uniqKey="Lazzarini A" first="Alice M." last="Lazzarini">Alice M. Lazzarini</name>
<name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F." last="Lew">Mark F. Lew</name>
<name sortKey="Macdonald, Marcy E" sort="Macdonald, Marcy E" uniqKey="Macdonald M" first="Marcy E." last="Macdonald">Marcy E. Macdonald</name>
<name sortKey="Maher, Nancy E" sort="Maher, Nancy E" uniqKey="Maher N" first="Nancy E." last="Maher">Nancy E. Maher</name>
<name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name>
<name sortKey="Montgomery, Erwin" sort="Montgomery, Erwin" uniqKey="Montgomery E" first="Erwin" last="Montgomery">Erwin Montgomery</name>
<name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name>
<name sortKey="Reider, Carson R" sort="Reider, Carson R" uniqKey="Reider C" first="Carson R." last="Reider">Carson R. Reider</name>
<name sortKey="Saint Hilaire, Marie H" sort="Saint Hilaire, Marie H" uniqKey="Saint Hilaire M" first="Marie H." last="Saint-Hilaire">Marie H. Saint-Hilaire</name>
<name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
<name sortKey="Slater, Karen M" sort="Slater, Karen M" uniqKey="Slater K" first="Karen M." last="Slater">Karen M. Slater</name>
<name sortKey="Stacy, Mark" sort="Stacy, Mark" uniqKey="Stacy M" first="Mark" last="Stacy">Mark Stacy</name>
<name sortKey="Sullivan, Kristin M" sort="Sullivan, Kristin M" uniqKey="Sullivan K" first="Kristin M." last="Sullivan">Kristin M. Sullivan</name>
<name sortKey="Waters, Cheryl H" sort="Waters, Cheryl H" uniqKey="Waters C" first="Cheryl H." last="Waters">Cheryl H. Waters</name>
<name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name>
<name sortKey="Wilk, Jemma B" sort="Wilk, Jemma B" uniqKey="Wilk J" first="Jemma B." last="Wilk">Jemma B. Wilk</name>
<name sortKey="Wooten, G Frederick" sort="Wooten, G Frederick" uniqKey="Wooten G" first="G. Frederick" last="Wooten">G. Frederick Wooten</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
</region>
<name sortKey="Labelle, Nancy" sort="Labelle, Nancy" uniqKey="Labelle N" first="Nancy" last="Labelle">Nancy Labelle</name>
<name sortKey="Lafontaine, Anne Louise" sort="Lafontaine, Anne Louise" uniqKey="Lafontaine A" first="Anne-Louise" last="Lafontaine">Anne-Louise Lafontaine</name>
<name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Vieregge, Peter" sort="Vieregge, Peter" uniqKey="Vieregge P" first="Peter" last="Vieregge">Peter Vieregge</name>
</noRegion>
<name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
</country>
<country name="Italie"><noRegion><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

PARK3 influences age at onset in parkinson disease: A genome scan in the GenePD study

PARK3 influences age at onset in parkinson disease: A genome scan in the GenePD study

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